AUA1
AUA1 is a monoclonal antibody identifying a human cell surface antigen of the same name. The protein is encoded by a gene on chromosome 2, MIC 18, and has a molecular weight of 35 kD.
Immunohistochemical expression
A limited range of normal epithelia and many epithelial neoplasms.
Histological study:
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reactive mesothelium
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0/9(four patients with recurrent pneumothoraces, five with non-neoplastic causes of pleural effusion)2
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mesothelioma
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0/8In all cases the diagnosis was confirmed ultrastructurally)2
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adenocarcinoma involving pleura
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13/14(7 primary pulmonary, five metastases from breast, one from colon and one from an unknown primary: staining occurred along the non-luminal cell membrane)2
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Cytological study:
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benign effusions
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2/84(the two positive effusions contained cells from the Fallopian tube and an ovarian adenofibroma respectively.)1
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malignant effusions
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46/52(this short paper is a little vague, but it seems these malignancies were epithelial)1
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Diagnostic utility
Differentiation of adenocarcinoma from epithelioid mesothelioma: it has mostly been used by cytopathologists.
References
1 Kocjan G, Sweeney E, Miller KD, et al. AUA1: new immunocytochemical marker for detecting epithelial cells in body cavity fluids. J Clin Pathol 1992; 45:358-9 FULL TEXT
2 Soosay GN, Griffiths M, Papadaki L, et al. The differential diagnosis of epithelial-type mesothelioma from adenocarcinoma and reactive mesothelial proliferation. J Pathol 1991; 163:299-305
This page last revised 24.5.2006.
©SMUHT/PW Bishop