Differentiation of Sertoli cell tumour, endometrioid tumours and carcinoid tumour

It is well recognised that endometrioid adenocarcinoma of the ovary may mimic Sertoli-cell tumour. Less often, sex cord stromal tumours with tubules of Sertoli cell type may mimic endometrioid carcinoma.

Tubule-rich ovarian tumours include Sertoli cell tumour, endometrioid tumours and carcinoid tumour.

		Sertoli cell tumour	Borderline endometrioid tumour	Sertoliform endometrioid carcinoma	Well-differentiated endometrioid carcinoma	Carcinoid tumour	Diagnostic value
	number of cases	40	38	13	27	42
	CK7	13% (staining frequently focal)	100% (staining frequently diffuse)	85% (staining frequently diffuse)	100% (staining frequently diffuse)	24% (staining frequently focal)	positivity favours endometrioid carcinoma
	ER	8% (staining focal)	87% (staining frequently diffuse)	85% (staining frequently diffuse)	89% (staining frequently diffuse)	2% (staining focal)	positivity favours endometrioid carcinoma
	PR	13% (staining focal)	84% (staining frequently diffuse)	77% (staining frequently diffuse)	93% (staining frequently diffuse)	2% (staining focal)	positivity favours endometrioid carcinoma
	pan CK	65% (staining variable)	100% (staining frequently diffuse)	100% (staining frequently diffuse)	100% (staining frequently diffuse)	98% (staining frequently diffuse)	not useful
	CK8/18	43% (staining variable)	100% (staining frequently diffuse)	93% (staining frequently diffuse)	96% (staining frequently diffuse)	74% (staining frequently diffuse)	not useful
	EMA	0%	100% (staining frequently diffuse)	100% (staining frequently diffuse)	100% (staining frequently diffuse)	12% (staining focal)	positivity favours endometrioid carcinoma
	CD10	25% (staining variable)	39% (staining variable)	31% (staining variable)	37% (staining variable)	9% (staining variable)	not useful
	Inhibin	98% (staining frequently diffuse)	0%	0%	4% (staining focal)	2% (staining focal)	positivity favors Sertoli cell tumour
	Calretinin	60% (staining frequently diffuse)	11% (staining focal)	0%	18% (staining focal)	0%	positivity favors Sertoli cell tumour
	CD99	68% (staining variable)	16% (staining variable)	23% (staining variable)	33% (staining variable)	40% (staining variable)	not useful
	CD56	48% (staining focal to variable)	16% (staining focal to variable)	16% (staining focal to variable)	30% (staining focal to variable)	57% (staining diffuse)	not useful
	Synaptophysin	35% (staining focal)	8% (staining focal)	8% (staining focal)	22% (staining focal)	98% (staining frequently diffuse)	positivity favours carcinoid tumour
	Chromogranin	13% (staining focal)	3% (staining focal)	15% (staining focal)	11% (staining focal)	100% (staining frequently diffuse)	positivity favours carcinoid tumour

References

¹ Zhao C, Bratthauer GL, Barner R, et al. Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases. Am J Surg Pathol 2007; 31:255-66

This page last revised 17.2.2007.

©SMUHT/PW Bishop