Foxn1

FoxN1 is a member of the winged helix/forkhead family of transcription factors. It is a factor in thymic and parathyroid organogenesis.

Immunohistochemical expression

Expression is nuclear.

Normal thymic epithelial cells, both cortical and medullary1.

	Multiple normal tissues		0/481
	Skin	squamous cell carcinoma	9/711
	Skin	basal cell carcinoma	0/291
	Lung	adenocarcinoma	0/201
		squamous cell carcinoma	0/521
		large cell carcinoma	0/31
	Multiple other sites	squamous cell carcinoma	0/981
	Multiple other sites	adenocarcinoma	0/291

Thymic tumours, benign and malignant: staining is strong nuclear in thymomas, focal in thymic carcinomas.

Diagnostic utility

Diagnosis of thymoma

References

1 Nonaka D, Henley JD, Chiriboga L, et al. Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. Am J Surg Pathol 2007; 31:1038-44

This page last revised 11.11.2007.

©SMUHT/PW Bishop