Hepatoid adenocarcinoma of the gallbladder

Definition

A rare tumour consisting of a combination of adenocarcinoma and foci resembling neoplastic hepatocytes.

Immunohistochemistry

	CK7	0/21
	CK8	2/21
	CK19	2/21
	Hep-Par-1	2/21
	a-fetoprotein	1/21
	CD10	2/2(canalicular)1
	pCEA	canalicular

Differential diagnosis

Hepatocellular carcinoma infiltrating gallbladder. Hepatocellular carcinoma is generally negative for CK19.
Adenocarcinoma of gallbladder infiltrating liver.

References

1 Sakamoto K, Kimura N, Tokumura H, et al. Hepatoid adenocarcinoma of the gallbladder. Histopathology 2005; 47:649-51

This page last revised 4.3.2006.

©SMUHT/PW Bishop