Protein Gene Product 9.5 (PGP 9.5)

Staining is more intense with less background than for NSE.

Immunohistochemical expression

• central and peripheral nervous system

• neuroendocrine cells

• renal tubules

• spermatogonia

• non-pregnant corpus luteum

• follicle centre cells

• pituitary adenoma

• see comparison of neuroendocrine markers

• medullary carcinoma of thyroid

• pancreatic islet cell tumour

• paraganglioma

• neuroblastoma

• carcinoid tumours

• Merkel cell carcinoma

Diagnostic utility

• identification of neuroendocrine differentiation, but its specificity is low

• identification of atrial myxomas

References

©SMUHT/PW Bishop