Endometrial versus endocervical carcinoma, Kamoi et al1

"positive": score > 3

Endometrial

Endocervical

Conclusion

endometrioid

mucinous

endometrioid

mucinous

 mean (range)

positive

 mean (range)

positive

 mean (range)

positive

 mean (range)

positive

ER

5.7 (0-12)

20/27

4.2 (0-12)

9/17

1.6 (0-6)

1/5

0

1/10

score relates mainly to site

PR

7.6 (0-12)

24/27

2.8 (0-6)

7/17

6.0 (0-12)

3/5

0.1 (0-1)

1/10

score relates mainly to type

CK4

9.2 (0-12)

 

4.4 (0-12)

 

10.6 (8-12)

 

8.5 (6-12)

 

not useful

CK18

6.4 (0-12)

 

3.4 (0-8)

 

8.4 (6-12)

 

5.5 (0-12)

 

not useful

CK20

0.7 ( 0-12)

 

0

 

0.4 (0-2)

 

0.5 (0-1)

 

almost always negative

CEA

0.4 (0-6)

2/27

0.9 (0-6)

1/17

1.2 (0-6)

1/5

5.1 (1-12)

5/10

 scores highly only in some mucinous endocervical carcinomas

Vimentin

6.9 ( 0-12)

24/27

1.9 ( 0-12)

3/17

4.4 (0-12)

2/5

0

0/10

scores highly only in endometrial endometrioid carcinomas

                   

Immunoreactivity was scored as for the German Immunohistochemical Scoring System:

percentage of positive cells (PPS); 0=negative, 1 = up to 10% positive, 2 = 11 to 50% positive, 3 = 51 to 80% positive, 4 = more than 800% positive

Staining intensity (SI); 0 = negative, 1 = weak, 2 = moderate, 3 = strong.

Score = PSS x SI (maximum score = 12). A score of 3 or less is essentially "negative".

References

1Kamoi, S., M. I. AlJuboury, et al. (2002). "Immunohistochemical staining in the distinction between primary endometrial and endocervical adenocarcinomas: another viewpoint." Int J Gynecol Pathol 21(3): 217-23.

This page last revised 4.5.2004.

©SMUHT/PW Bishop