Splenic micronodular large B-cell lymphoma (SMLBCL)

Involves the splenic white pulp in a micronodular pattern but spares the red pulp.

T cells

CD3

positive

histiocytes

CD68

positive

B cells

CD20

positive

CD79a

positive

bcl-6

positive

Oct-2

positive

bcl-2

positive

CD10

negative

CD138

negative

EBV-LMP-1

negative

EBER

negative

CD30

variable

EMA

variable

follicle dendritic cells

CD21

absent

CD35

Differential diagnosis:

References:

Dogan A, Isaacson PG. Micronodular (T-cell/histiocyte rich) large B-cell lymphoma of the spleen: histology, immunophenotype and differential diagnosis. J Pathol 2001;193 (suppl):20A.

Dogan A, Burke JS, Goteri G, et al. Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. Am J Surg Pathol 2003; 27:903-11