Granulosa cell tumour of testis, juvenile type

Epidemiology

Usually occurs in infants less than six months old.

Clinical features

Hormonal manifestations are rare.

Histopathology

Solid aggregates of tumour cells with large follicle-like cystic spaces containing basophilic mucoid fluid. Nuclear grooves and Call-Exner bodies are usually not seen.

Immunohistochemistry

Cam5.2	focally positive3
muscle-specific actin	may be positive3
desmin	may be positive3
vimentin	positive3
CD99	3/52
inhibin	4/52

Differential diagnosis

• Sertoli cell tumour, NOS

• Yolk sac tumour; usually older than six months, strongly cytokeratin and aFP positive.

Prognosis

Malignant behaviour has not been reported.

References

¹Shanks JH, Iczkowski KA. Non-germ cell tumours of the testis. Current Diagnostic Pathology 2002;8:83-93.

²Kommoss, F., Oliva, E., Bittinger, F., Kirkpatrick, C. J., Amin, M. B., Bhan, A. K., Young, R. H., Scully, R. E. Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Hum Pathol 2000;31:1055-61.

³Perez-Atayde, A. R., Joste, N., Mulhern, H. Juvenile granulosa cell tumor of the infantile testis. Evidence of a dual epithelial-smooth muscle differentiation. Am J Surg Pathol 1996;20:72-9.

This page last revised 2.12.2002.

©SMUHT/PW Bishop