Immunohistochemistry
|
intratubular germ cell neoplasia |
spermatocytic seminoma |
choriocarcinoma |
|||||
|
cytokeratin |
- |
syncytiotrophoblastic cells only + |
occasionally |
+ |
+ |
||
|
PLAP |
+ |
+ |
occasionally |
+ |
- |
||
|
NSE |
+ |
+ |
- |
+ |
|||
|
ferritin |
+ |
||||||
|
AFP |
- |
variable |
+ |
- |
|||
|
hCG |
- |
syncytiotrophoblastic cells only + |
syncytiotrophoblastic cells only + |
- |
var |
||
|
vimentin |
- |
var |
|||||
|
EMA |
- |
+ |
|||||
|
CD30 |
+ |
- |
- |
||||
|
CD15 |
usually negative |
- |
var |
||||
|
CEA |
usually negative |
- |
var |
||||
CD117 staining is membranous in intratubular germ cell neoplasia and seminoma, but cytoplasmic in non-seminomatous germ cell neoplasms2.
References
Diagnostic histopathology of tumors. Edited by CDM Fletcher. 2nd edition. Churchill Livingstone. Pages 783-795.