Leiomyosarcoma

Histopathology

Leiomyosarcoma show fascicles of spindle cells with eosinophilic delicately fibrillary cytoplasm, hyperchromatic blunt-ended (cigar-shaped) nuclei and paranuclear vacuoles. There may be myxoid areas or metaplastic bone formation.

Variants:

Immunohistochemistry

desmin

50-100%

relatively specific

SMA

90%

less specific

HHF35

positive

not specific

Pancytokeratin

38/1001

 

Cytokeratin 1

0/101

 

Cytokeratin 5/6

1/121

 

Cytokeratin 7

0/121

 

Cytokeratin 8 / 18

14/401

 

Cytokeratin 13

0/191

 

Cytokeratin 14

1/121

 

Cytokeratin 19

1/191

 

Cytokeratin 20

0/121

 

S-100

occasional

 

Leu-7

occasional

 

b-catenin

occasional

 

myelin basic protein

occasional

 
     

Further information is available on these tumours at specific sites:

Differential diagnosis: see the immunohistochemistry of the differential diagnosis of spindle cell stromal tumours.

References

1Chu, P. G. and L. M. Weiss (2002). "Keratin expression in human tissues and neoplasms." Histopathology 40(5): 403-39. (Summary data from multiple papers)

 

This page last revised 4.1.2004.

©SMUHT/PW Bishop