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Prologue
Title page
Introduction
Web site status
Updates and news
May 2008
January 2008
May 2007
January 2007
October 2006
May 2006
January 2006
July 2005
January 2005
September 2004
May 2004
January 2004
September 2003
June 2003
April 2003
January 2003
November 2001
Links
General references
Future of immunohistochemistry
Technical aspects
Rabbit monoclonal antibodies
Techniques for small lesions
Tissue microarray technology
NCBI's disclainer and copyright notice
Tumours
Skin
Cutaneous collagenoma
Acral fibromyxoma
Juvenile xanthogranuloma
Atypical fibroxanthoma
Melanoma
Melanocytic maturational immunohistochemistry
Desmoplastic melanoma
Glomus tumour
Primitive non-neural granular cell tumour of the skin
Cutaneous PEComa
Microcystic adnexal carcinoma
p63 in cutaneous adnexal neoplasms
Paraganglioma-like dermal melanocytic tumour
Primary mucinous carcinoma of the skin
Merkel cell carcinoma
Merkel cell carcinoma
Merkel v metastatic small cell carcinoma
Basal cell v squamous cell vs basosquamous carcinoma
Basal cell carcinoma vs sebaceoma
Differential diagnosis of cutaneous and subcutaneous myxoid lesions
Papillary haemangioma
CD30 positive cells in cutaneous inflammatory lesions
Cutaneous mesenchymal tumours
Fibrous histiocytoma
Angioleiomyoma
Atypical vascular lesions
Cutaneous angiosarcoma
Cutaneous B-cell lymphomas
Cutaneous B-cell lymphomas
Primary cutaneous marginal zone B-cell lymphoma
Primary cutaneous follicular lymphoma
Cutaneous diffuse large B-cell lymphomas, primary and secondary
Cutaneous T-cell lymphoproliferative disorders
Indolent CD8-positive lymphoid proliferation of the ear
Upper aerodigestive tract
Nasopharyngeal angiofibroma
Sinonasal haemangiopericytoma
Schneiderian papilloma
Low-grade sinonasal adenocarcinoma of the nasal sinuses
Sinonasal adenocarcinoma, intestinal type
Sinonasal undifferentiated carcinoma
Extranodal NK/T-cell lymphoma, nasal type
Thymic carcinoma with t(15;19) translocation
Olfactory neuroblastoma
Endolymphatic sac tumour
Sinonasal melanoma
Leiomyosarcoma of the head and neck
Lingual alveolar soft part sarcoma
Nasal angiomyolipoma
Ceruminous adenoma
Neuroendocrine adenoma of the middle ear
Salivary gland tumours
Salivary gland tumours
Epithelial tumours of salivary glands
Pleomorphic adenoma
Carcinoma ex pleomorphic adenoma of salivary gland
Myoepithelioma
Canalicular adenoma
Adenoid cystic carcinoma
Mucoepidermoid carcinoma of salivary gland
Acinic cell tumour
Polymorphous low-grade adenocarcinoma
Low-grade salivary duct carcinoma
Epithelial-myoepithelial carcinoma of the salivary gland
Basal cell carcinoma of salivary gland
Hyalinising clear cell carcinoma of the salivary gland
Sclerosing polycystic adenosis of the salivary gland
Keratocystoma of salivary gland
Smalll cell carcinoma of salivary gland
Chronic sclerosing sialadenitis
Lung
Benign epithelial tumours
Squamous cell papilloma of the lung
Glandular papilloma of the lung
Mixed squamous cell and glandular papilloma of the lung
Alveolar adenoma
Pulmonary papillary adenoma
Mucous gland adenoma
Pleomorphic adenoma of the lung
Mucinous cystadenoma of the lung
Pneumocytic adenomyoepithelioma
Malignant epithelial tumours
Malignant epithelial tumours
Squamous cell carcinoma of lung
Small cell carcinoma of the lung
Adenocarcinoma
Adenocarcinoma
Mucinous Carcinoma of lung
Micropapillary carcinoma of lung
Primary signet-ring cell carcinoma of lung
Pulmonary adenocarcinoma with enteric differentiation
Large cell carcinoma of the lung
Adenosquamous carcinoma of the lung
Sarcomatoid carcinoma of lung
Carcinoid tumour
Carcinoid tumour
Carcinoid: pulmonary v gastrointestinal v pancreatic
Salivary gland type tumours of the lung
Salivary gland type tumours of the lung
Mucoepidermoid tumour of the lung
Adenoid cystic carcinoma of the lung
Epithelial-myoepithelial carcinoma of bronchus
Malignant epithelial tumours: cytokeratins and neuroendocrine markers
TMN staging of carcinomas of the lung
Salivary gland tumours of the lung
Salivary gland tumours of the lung
Pleomorphic adenoma of the lung
Epithelial-myoepithelial carcinoma of bronchus
Mucoepidermoid tumour of the lung
Adenoid cystic carcinoma of the lung
Lymphoproliferative tumours
Lymphoproliferative tumours
Marginal zone B-cell lymphoma of the lung
Diffuse large B-cell lymphoma of the lung
Lymphomatoid granulomatosis
Langerhans' cell histiocytosis of the lung
Mesenchymal tumours
Epithelioid haemangioendothelioma
Pleuropulmonary blastoma
Chondroma
Pulmonary microcystic fibromyxoma
Congenital peribronchial myofibroblastic tumour
Diffuse pulmonary lymphangiomatosis
Inflammatory pseudotumour of the lung
Lymphangioleiomyomatosis
Intrathoracic synovial sarcoma
Miscellaneous tumours
Traumatic neuroma of the bronchial stump
Hamartoma
Pulmonary adenofibroma
Sclerosing haemangioma
Clear cell tumour of the lung
Teratoma of the lung
Intrapulmonary thymoma
Pulmonary melanoma
Pulmonary meningioma
Diffuse meningotheliomatosis of the lung
Differential diagnosis of spindle cell tumours of the lung
Sustentacular cells in neuroendocrine tumours of the lung
Pleura
Benign pleural tumours
Solitary fibrous tumour of the pleura
Nodular pleural plaque
Lipomatous pleural tumours
Adenomatoid tumour of the pleura
Calcifying fibrous tumour of the pleura
Simple mesothelial cysts
Multicystic mesothelioma
Pleural Schwannoma
Pleural tumours of low malignant potential
Primary pleural thymic epithelial tumours
well-differentiated papillary mesothelioma
Desmoid tumour of the pleura
Mesothelioma
Mesothelioma
Mesothelioma v adenocarcinoma
Lymphohistiocytoid malignant mesothelioma
Well-differentiated papillary mesothelioma
Localised malignant mesothelioma
Reactive mesothelium versus malignant mesothelioma
Carcinoma in effusions
Renal cell carcinoma vs mesothelioma
Rare malignant mesothelial tumours
Desmoplastic small round cell tumour
Malignant solitary fibrous tumour
Intrathoracic synovial sarcoma
Synovial sarcoma vs mesothelioma
Ewing family tumour
Pleuropulmonary blastoma
Pleural liposarcoma
Pleural vascular sarcoma
Differential of spindle cell tumours of the pleura
Pyothorax-associated lymphoma
Primary effusion lymphoma
Mediastinum
Thymus
Thymoma, types A & B
Thymoma, types A & B
Thymoma cytokeratin profiles
Type A thymoma
Type AB thymoma
Type B1 thymoma
Type B2 thymoma
Type B3 thymoma
Rare thymoma subtypes
Metaplastic thymoma
Thymic low grade metaplastic carcinoma
Micronodular thymoma with lymphoid B-cell hyperplasia
Microscopic thymoma
Sclerosing thymoma
Lipofibroadenoma of the thymus
Type X thymoma
Thymic carcinomas
Thymic carcinomas
Squamous cell carcinoma of the thymus
Epidermoid non-keratinising carcinoma of the thymus
Clear cell carcinoma of the thymus
Basaloid carcinoma of the thymus
Mucoepidermoid carcinoma of the thymus
Mucinous adenocarcinoma of the thymus
Papillary carcinoma of the thymus
Non-papillary adenocarcinoma of the thymus
Lymphoepithelioma-like carcinoma of the thymus
Sarcomatoid carcinoma of the thymus
Spindle cell carcinoma of the thymus
Hepatoid carcinoma of the thymus
Thymic carcinoma with t(15;19) translocation
Undifferentiated carcinoma of the thymus
Thymic Carcinoma Arising in Thymoma
Combined thymomas
Neuroendocrine tumours of the thymus
Neuroendocrine tumours of the thymus
Thymic carcinoid tumour
Thymic spindle cell carcinoid
Thymic pigmented carcinoid tumour
Thymic small cell carcinoma
Thymic large cell neuroendocrine carcinoma
Differentiation of thymoma from oesophageal carcinoma, lung carcinoma and mesothelioma
Ectopic hamartomatous thymoma
Rare thymic tumours
Thymolipoma
Intrathoracic synovial sarcoma
Mediastinal gray zone lymphoma
Germ cell tumours of the mediastinum
Seminoma of the mediastinum
Embryonal carcinoma of the mediastinum
Yolk sac tumour of the mediastinum
Choriocarcinoma of the mediastinum
Teratoma of the mediastinum
Sclerosing paraganglioma
Mediastinal liposarcoma
Heart
Cardiac myxoma
Imflammatory myofibroblastic tumour of the heart
Primary cardiac sarcomas
Oral cavity
ameloblastoma
Gastrointestinal tract
Oesophagus
Oesophageal epithelium
Merkel cell carcinoma of the oesophagus
Stomach
Gastric adenocarcinoma, cytokeratins
Gastrointestinal glomus tumour
Gastrointestinal stromal tumours
Schwannoma of the gastrointestinal tract
Plexiform angiomyxoid myofibroblastic tumour of the stomach
Synovial sarcoma of the stomach
Gastrointestinal diffuse large B cell lymphoma
Small intestine
Small intestinal adenocarcinoma: cytokeratins 7 and 20
Carcinoma of the ampulla of Vater
Carcinoid tumours of duodenum and ampulla of Vater
High-grade neuroendocrine carcinoma of the Ampulla of Vater
Gastrointestinal tumours of the small intestine
Colorectum and anus
Colorectal adenocarcinoma, cytokeratins
Micropapillary carcinoma of the colon
Colorectal small cell carcinoma
Fibroblastic polyps of the colon
Paget's disease
Gastrointestinal stromal tumours of the colon
Lymphomatous polyposis
Gastrointestinal stromal tumour of the anorectum
Mucosal Benign Epithelioid Nerve Sheath Tumors
Anal intraepithelial neoplasia
Gastrointestinal diffuse large B cell lymphoma
Gastrointestinal stromal tumours
Gastrointestinal stromal tumours
Gastrointestinal tumours of the small intestine
Gastrointestinal stromal tumours of the colon
Gastrointestinal stromal tumour of the anorectum
Gastrointestinal stromal tumour of the soft tissue
Gastrointestinal autonomic nerve tumour
KIT-negative GISTs
GISTs in neurofibromatosis I
Gastrointestinal lymphoproliferative disorders
Granular cell tumour of the gastrointestinal tract
Pancreas
Pancreatic tumours differential diagnosis
Solid-pseudopapillary tumour of the pancreas
Pancreatic adenocarcinoma, cytokeratins
Claudin 18 and annexin 8 in pancreatic carcinoma
Pancreatic endocrine tumours
Lipid-Rich Variant of Pancreatic Endocrine Neoplasms
Hepatoid carcinoma of the pancreas
Carcinoid: pulmonary v gastrointestinal v pancreatic
Liver
Hepatocellular carcinoma v cholangiocarcinoma v metastatic adenocarcinoma
Combined hepatocellular-cholangiocarcinoma
Carcinosarcoma of the liver
Hepatoid adenocarcinoma of the gallbladder
Clear cell cholangiocarcinoma
Granular cel tumour of the biliary tract
Breast
Breast pathology, assessing stromal invasion
Breast carcinoma in situ, ductal versus lobular
Breast - specific cytokeratins
Breast cancer - steroid receptors
Breast carcinoma vs other adenocarcinomas
Tubulolobular carcinoma of the breast
Oncocytic carcinoma of the breast
E-Cadherin, catenin and CD44 in breast carcinoma
Mammary intra-epithelial neoplasia
Micropapillary carcinoma of the breast
Apocrine carcinoma of the breast
Salivary gland-like tumours of the breast
Salivary gland-like tumours of the breast
Adenoid cystic carcinoma of the breast
Small cell carcinoma of the breast
Papilloma versus papillary DCIS of the breast
Paget's disease
Pseudoangiomatous stromal hyperplasia of the breast
mammary myofibroblastoma
Periductal stromal tumour of the breast
metaplastic carcinoma and the differential of spindle cell tumours of the breast
low-grade spindle cell carcinoma of the breast
Bone
Fibrous and osteofibrous dysplasia of bone
Rosette-forming epithelioid osteosarcoma
small cell osteosarcoma
Ewing family tumour
Clear cell chondrosarcoma
chordoma
chordoma
Extra-axial chordoma
myofibrosarcoma of bone
malignant fibrous histiocytoma of bone
Genitourinary
Kidney
Renal neoplasms - overview
Renal cortical adenoma
Metanephric adenoma
Metanephric adenofibroma
Renal oncocytoma
Renal clear cell carcinoma
Papillary renal cell carcinoma
Papillary renal cell carcinoma
Adult papillary renal tumour with oncocytic cells
Chromophobe renal cell carcinoma
Collecting duct carcinoma
Tubulocystic carcinoma of the kidney
Paediatric renal cell carcinoma
Mucinous tubular and spindle cell carcinoma
Renal mixed epithelial and stromal tumour
Carcinoid tumour of the kidney
Anaplastic sarcoma of the kidney
Hereditary leiomyomatous and renal cell carcinoma syndrome
Thyroid Follicular Carcinoma-like Tumor of Kidney
Renal spindle cell tumours
Juxtaglomerular cell tumour
Ewing's sarcoma - primitive neuroectodermal tumour of kidney
Angiomyolipoma
Glomus tumour of the kidney
Malignant rhabdoid tumour
Bladder
Cytokeratins in urothelium
S100P & GATA3 in urothelial carcinoma
Lipoid-cell urothelial carcinoma
Smooth muscle tumours of the urinary bladder
Urothelium normal v reactive v carcinoma in situ
Differentiation of inverted papilloma from inverted-pattern carcinoma
Differentiation primary adenocarcinoma bladder & secondary colorectal carcinoma
Small cell carcinoma of the bladder
Inflammatory myofibroblastic tumour of the bladder
Nephrogenic adenoma
Ovary
Ovarian tumours - immunohistochemistry
Serous carcinoma of ovary
Mucinous tumour of the ovary associated with mature cystic teratoma
Granulosa cell tumour of the ovary with a pseudopapillary pattern
Non-small cell neuroendocrine carcinoma of the ovary
Differentiation of peritoneal mesothelioma and serous carcinoma
Sarcoma-like mural nodules in mucinous cystic tumour of the ovary
Differentiation of primary ovarian tumours from metastatic colorectal carcinoma
Differentiation of primary ovarian carcinoma from metastatic breast carcinoma
Differentiation of Sertoli cell tumour, endometrioid tumours and carcinoid tumour
Lung carcinoma metastatic to the ovary
Appendiceal signet ring cell carcinoid-like tumours metastatic to ovary
Germ cell tumours of ovary
Yolk sac tumour of ovary
Yolk sac tumour of ovary
Hepatoid yolk sac tumour of ovary
Sertoli cell tumour of the ovay
Sertoli cell tumour of the ovay
Sertoli-stromal cell tumour of the ovary
Retiform Sertoli-Leydig cell tumour of the ovary
Pseudoendometrioid Sertoli-Leydig cell tumour
GIST metastatic to ovary
Malignant melanoma of ovary
Small cell carcinoma of ovary
Uterus
Endometrial carcinoma, steroid receptor content
Endocervical v endometrial adenocarcinoma
Endometrial carcinoma, types 1 vs type 2
Endometrial stromal sarcoma
Endometrioid Carcinomas of the Uterine Corpus With Sex Cord-like Formations
Focal uterine serous carcinoma
Perivascular epithelioid tumour of the uterus
Trophoblastic tumour
Trophoblastic tumour
Epithelioid trophoblastic tumour
Choriocarcinoma
Hydatidiform mole, complete v partial v choriocarcinoma v placental site tumour
Wolffian adnexal tumour
Neuroectodermal tumour of the uterus
Vulva and vagina
Soft tissue tumours of the vulva
Angiomyofibroblastoma
Cellular angiofibroma
Cervicovaginal myofibroblastoma
Vaginal melanoma
Tubulo-squamous polyp of the vagina
Paget's disease
Prepubertal vulval fibroma
Lymphomas of the female genital tract
Prostate
Prostatic minimal carcinoma and its mimics
Prostatic basal cell proliferations
Solitary fibrous tumour of the prostate
Testis
Testicular germ cell tumours
Testicular germ cell tumours
Seminoma
Embryonal carcinoma
Yolk sac tumour
Teratoma
Cystic trophoblastic tumour
Testicular non-germ cell tumours
Leydig cell tumours of the testis
Sertoli cell tumour of testis, NOS
Large cell calcifying Sertoli cell tumour
Seminoma-like Sertoli cell tumour
Granulosa cell tumour of testis, adult type
Granulosa cell tumour of testis, juvenile type
Sex cord-stromal tumour of testis, mixed and unclassified
Diffuse large B-cell lymphoma of the testis
Mesothelioma of the tunica vaginalis
Follicular lymphoma of the testis
Seminal vesicle adenocarcinoma
Synovium
primary synovial chondromatosis
Brain
Glioblastoma multiforme
Angiocentric glioma
Oligosarcoma
Meningioma
Choroid plexus tumours
medulloblastoma
Paediatric CNS atypical teratoid/rhabdoid tumour
Thyroid
Thyroid
Follicular neoplasms of the thyroid
Papillary carcinoma of the thyroid
Papillary carcinoma of the thyroid
Oncocytic papillary carcinoma of the thyroid with lymphoid stroma
Childhood papillary carcinoma of the thyroid
Immunohistochemistry in the differential diagnosis of thyroid neoplasms
Insular carcinoma of the thyroid
Anaplastic carcinoma of the thyroid
Anaplastic and giant cell carcinoma of the thyroid
Medullary carcinoma of the thyroid
Hyalinising trabecular tumour thyroid
Primary squamous cell carcinoma of the thyroid
c-erbB-2 in thyroid tumours
Carcinoma showing thymus-like differentiation of the thyroid
Thyroid lymphoma
Solitary fibrous tumour of the thryoid
Parathyroid
oxyphil parathyroid neoplasms
Adrenal
Primary adrenal tumours
Adrenocortical carcinoma
Adrenal cortical paediatric neoplasms
Pheochromocytoma
Adrenal lipomatous tumours
Adrenal Myelolipoma
Sustentaculoma
Eye
Ciliary body adenocarcinoma
Giant cell angiofibroma
Lymphoma of ocular adnexa
Lymphoma of ocular adnexa
Ocular MALT lymphoma
Haematolymphoid
Inflammatory pseudotumour of lymph node
Autoimmune lymphoproliferative syndrome due to Fas mutation
Precursor B and T cell neoplasms
Precursor B lymphoblastic leukaemia / lymphoma
Precursor T lymphoblastic lymphoma / leukaemia
Mature B cell neoplasms
Mature B cell neoplasms
Chronic lymphocytic leukaemia / small cell lymphocytic lymphoma
B-cell prolymphocytic leukaemia
Lymphoplasmacytic lymphoma / Waldenström macroglobulinaemia
Hairy cell leukaemia
Plasma cell myeloma
Extranodal marginal zone B-cell lymphoma
Extranodal marginal zone B-cell lymphoma
Nodal involvement in gastric MALT lymphoma
Splenic marginal-zone lymphoma
Marginal zone B-cell lymphoma of the lung
Ocular MALT lymphoma
Nodal marginal zone B-cell lymphoma
Follicular lymphoma
Mantle cell lymphoma
Diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma
T-cell rich B-cell lymphoma
Mediastinal large B-cell lymphoma
Mediastinal gray zone lymphoma
Intravascular large B-cell lymphoma
Gastrointestinal diffuse large B cell lymphoma
ALK+ DLBCL
ALK+ DLBCL
Diffuse large B-cell lymphoma with expression of full-length ALK
Diffuse large B-cell lymphoma with CLTC-ALK fusion product
Pyothorax-associated lymphoma
Large B-cell lymphoma presenting in the spleen
Primary effusion lymphoma
Primary effusion lymphoma
Extra-cavitary PEL
Burkitt lymphoma
Atypical Burkitt-like lymphoma
Lymphomatoid granulomatosis
Differential of low grade B cell lymphomas
Mature T-cell and NK-cell neoplasms
Mature T-cell and NK-cell neoplasms
T-cell prolymphocytic leukaemia
T-cell large granular lymphocyte leukaemia
Aggressive NK-cell leukaemia
Adult T cell lymphoma / leukaemia
Extranodal NK/T-cell lymphoma, nasal type
Enteropathy-type T-cell lymphoma
Hepatosplenic T-cell lymphoma
Mycosis fungoides / Sezary's syndrome
Subcutaneous panniculitis-like T-cell lymphoma
Blastic NK-cell lymphoma
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders
Angioimmunoblastic T cell lymphoma